| Friday 2nd April 2010 | ||||
| Guinness Premiership | ||||
| Sale | v | Worcester | Edgeley Park | (19:45) |
| The Magners League | ||||
| Connacht | v | Edinburgh | The Sportsground | (15:00) |
| Glasgow Warriors | v | The Dragons | Firhill | (15:00) |
| Munster | v | Leinster | Thomond Park, Limerick | (15:00) |
| The Ospreys | v | Scarlets | Liberty Stadium, Swansea | (15:00) |
| Ulster | v | Cardiff Blues | Ravenhill, Belfast | (15:00) |
| Saturday 3rd April 2010 | ||||
| Guinness Premiership | ||||
| Leicester | v | Bath | Welford Road | (15:00) |
| Harlequins | v | Newcastle | The Stoop | (15:00) |
| Gloucester | v | Saracens | Kingsholm | (15:00) |
| Sunday 4th April 2010 | ||||
| Guinness Premiership | ||||
| Leeds Carnegie | v | Northampton | Headingley | (15:00) |
| Wasps | v | London Irish | Adams Park | (15:00) |
| Friday 9th April 2010 | ||||
| Heineken Cup | ||||
| Leinster | v | Clermont Auvergne | Royal Dublin Showground | (20:00) |
| Saturday 10th April 2010 | ||||
| Heineken Cup | ||||
| Biarritz | v | The Ospreys | TBA | (16:00) |
| Munster | v | Northampton | Thomond Park, Limerick | (17:30) |
| Sunday 11th April 2010 | ||||
| Heineken Cup | ||||
| Toulouse | v | Stade Francais | Stade de Toulouse | (17:30) |
| Friday 16th April 2010 | ||||
| The Magners League | ||||
| Connacht | v | Munster | The Sportsground | (15:00) |
| Glasgow Warriors | v | Ulster | Firhill | (15:00) |
| Leinster | v | The Ospreys | Royal Dublin Showground | (15:00) |
| The Dragons | v | Edinburgh | Rodney Parade, Newport | (15:00) |
| Scarlets | v | Cardiff Blues | Parc y Scarlets, Llanelli | (15:00) |
| Saturday 17th April 2010 | ||||
| Guinness Premiership | ||||
| Northampton | v | Gloucester | Franklin's Gardens | (15:00) |
| Worcester | v | Wasps | Sixways Stadium | (15:00) |
| Sunday 18th April 2010 | ||||
| Guinness Premiership | ||||
| Saracens | v | Harlequins | Vicarage Road | (15:00) |
| London Irish | v | Leeds Carnegie | Madejski Stadium | (15:00) |
| Newcastle | v | Leicester | Kingston Park | (15:00) |
| Friday 23rd April 2010 | ||||
| Guinness Premiership | ||||
| Sale | v | Newcastle | Edgeley Park | (19:45) |
| The Magners League | ||||
| Munster | v | The Ospreys | Thomond Park, Limerick | (15:00) |
| Edinburgh | v | Ulster | Murrayfield, Edinburgh | (15:00) |
| Glasgow Warriors | v | Leinster | Firhill | (15:00) |
| The Dragons | v | Cardiff Blues | Rodney Parade, Newport | (15:00) |
| Scarlets | v | Connacht | Parc y Scarlets, Llanelli | (15:00) |
| Saturday 24th April 2010 | ||||
| Guinness Premiership | ||||
| Gloucester | v | London Irish | Kingsholm | (15:00) |
| Northampton | v | Saracens | Franklin's Gardens | (15:00) |
| Leicester | v | Harlequins | Welford Road | (15:00) |
| Sunday 25th April 2010 | ||||
| Guinness Premiership | ||||
| Leeds Carnegie | v | Worcester | Headingley | (15:00) |
| Wasps | v | Bath | Adams Park | (15:00) |