| Friday 7th May 2010 | ||||
| The Magners League | ||||
| Cardiff Blues | v | Munster | Cardiff City Stadium | (15:00) |
| Leinster | v | Edinburgh | Royal Dublin Showground | (15:00) |
| The Ospreys | v | The Dragons | Liberty Stadium, Swansea | (15:00) |
| Scarlets | v | Glasgow Warriors | Parc y Scarlets, Llanelli | (15:00) |
| Ulster | v | Connacht | Ravenhill, Belfast | (15:00) |
| Saturday 8th May 2010 | ||||
| Guinness Premiership | ||||
| Harlequins | v | Sale | The Stoop | (15:00) |
| Newcastle | v | Wasps | Kingston Park | (15:00) |
| Leicester | v | Saracens | Welford Road | (15:00) |
| London Irish | v | Northampton | Madejski Stadium | (15:00) |
| Worcester | v | Gloucester | Sixways Stadium | (15:00) |