| Friday 3rd September 2010 | ||||
| Aviva Premiership | ||||
| Sale | v | Newcastle | Edgeley Park | (19:45) |
| The Magners League | ||||
| Ulster | v | Ospreys | Ravenhill, Belfast | (19:05) |
| Saturday 4th September 2010 | ||||
| Aviva Premiership | ||||
| London Irish | v | Saracens | Madejski Stadium | (14:00) |
| Exeter | v | Gloucester | Sandy Park | (15:00) |
| Wasps | v | Harlequins | Adams Park | (16:30) |
| The Magners League | ||||
| Connacht | v | Newport-Gwent D'gons | Galway Sportsground | (17:30) |
| Cardiff Blues | v | Edinburgh | Cardiff City Stadium | (18:30) |
| Benetton Treviso | v | Scarlets | Stadio Comunale di Monigo | (19:05) |
| Munster | v | Aironi Rugby | Thomond Park, Limerick | (19:30) |
| Scottish Hydro Premiership Division One | ||||
| Selkirk | v | Watsonians | Philiphaugh | (15:00) |
| Dundee HSFP | v | Ayr | Mayfields | (15:00) |
| Boroughmuir | v | West of Scotland | Meggetland | (15:00) |
| Sunday 5th September 2010 | ||||
| Aviva Premiership | ||||
| Northampton | v | Leicester | Franklin's Gardens | (15:00) |
| Leeds Carnegie | v | Bath | Headingley | (15:00) |
