Tom Homer starts at full back and he will be joined by Adam Thompstone and Topsy Ojo in the back three. Jonathan Joseph replaces Elvis Seveali’i at outside centre and Richard Thorpe starts at number 8.
London Irish head coach Toby Booth said: “We have prepared well for Saturday’s game with Leicester and we know what is at stake.
We will approach the game in the same manner that we always do and look to come away with the right result.”
London Irish team to face Leicester:
15.Tom Homer; 14. Topsy Ojo*; 13.Jonathan Joseph; 12. Seilala Mapusua*; 11. Adam Thompstone; 10. Dan Bowden; 9. Paul Hodgson*; 1.Clarke Dermody* (Captain); 2. David Paice*; 3.Faan Rautenbach*; 4. Nick Kennedy*; 5. Bob Casey*; 6. Jamie Gibson; 7. Steffon Armitage*; 8. Richard Thorpe
Replacements: 16. James Buckland; 17.Alex Corbisiero*; 18. Max Lahiff; 19. Gary Johnson; 20. Chris Hala’ufia*; 21. Elvis Seveali’i*; 22. Chris Malone; 23. Darren Allinson
* Denotes international
Head Coach: Toby Booth; Attack Coach: Mike Catt; Defence Coach: Dave Ellis